Auto Sum is a feature that Excel gives you because the sum is the most calculation used in Excel.
Suppose we have the following table with Invoice Number and Invoice Amount.
Select cell B7
Go to the Formulas tab and press AutoSum
Note: You can use the shortcut = + Alt from the keyboard.
Excel will create an equation with the SUM function to add the range B2: B6, which is all numbers above cell B7
Press Enter and Excel will perform the equation.